Defining Contributions of Pancreatic Ductal and Acinar Cells to Tumorigenesis
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چکیده
The cellular origin of pancreatic tumors remains a vital topic for research to further our understanding of carcinogenesis. We currently do not know if cellular origin determines the phenotype of pancreatic tumors. Ninety percent of newly diagnosed pancreatic cancers are ductal adenocarcinomas (PDA). The majority of PDA are thought to originate from low-grade precursor tumors termed pancreatic intraepithelial neoplasms (PanIN) that progress into invasive adenocarcinoma in a step-wise fashion as they acquire more mutations [1].
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